This animated debacle lost over $100 million and is considered the worst flop of 2011. Lambasted by critics for its stiff, creepy motion-capture animation and rejected by audiences, 'Mars Needs Moms' caused studios to reconsider whether or not family-friendly CGI movies are really a safe bet.

Its failure, along with the similar audience rejection of movies like 'Red Planet,' inspired the makers of 'John Carter' to ditch the "of Mars" part of the Edgar Rice Burroughs' novels on which the film is based. Clearly Hollywood needs to stay off Mars.