It's March Madness, and we're ranking the stuff that really matters -- animals, cartoons, retro snacks and memes.

This is it – the Final Four!

One thing we're sure of -- the Not Sure If Fry meme has beaten All Your Base to the Final Four. Annoyed Picard continues in this enterprise as he sweeps All The Things. Condescending Wonka has shaken himself free of Overly Attached Girlfriend to move on solo to the next round. And nothing succeeds like Success Kid as he beats Disaster Girl to the Final Four sandbox.

Now who's ready for ROUND 3!!

Christine Gritmon

ROUND 3

Not Sure If Fry and Annoyed Picard both have lots of questions—whose curiosity will ultimately be satisfied? Will Condescending Wonka drown Success Kid in a river of chocolate, or will Success Kid simply paddle his way to victory? Vote below, and help us determine which TWO Internet Memes will make it to our final matchup!