Karen ”Duff” Duffy — MTV VJs Then and Now

Then: By 1989, Duffy was a working model and commercial actress. She joined MTV as a VJ in the early '90s, before landing a supporting role in the comedy smash 'Dumb & Dumber' as a tough-talking hitman hell-bent on whacking the titular dopey duo played by Jim Carrey and Jeff Daniels.

Now: In 1995, Duffy was diagnosed with sarcoidosis, a rare and incurable disease that assaults one's central nervous system. This slowed her down, but didn’t stop her. She went on work as a correspondent on two Michael Moore shows, first 'TV Nation,' then 'The Awful Truth.' Branching out into voice work, she played a recurring character on the spirited cartoon series 'Pepper Ann,' and lent her voice to Linda Otter in Wes Anderson's critically acclaimed adaptation of 'Fantastic Mr. Fox.' Plus, in 2000, she published a memoir titled, 'Model Patient: My Life as an Incurable Wise-Ass.'